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Do not take Clozaril with any of the following medications:

  • cisapride
  • medicines for treating cancer
  • mibefradil
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  • phenothiazines like perphenazine, thioridazine and chlorpromazine
  • pimozide
  • ziprasidone

Clozaril may also interact with the following medications:

  • caffeine
  • carbamazepine
  • cimetidine
  • ciprofloxacin
  • erythromycin or clarithromycin
  • lithium
  • medicines for anxiety or sleeping problems, such as diazepam or temazepam
  • medicines for colds, hay fever, and other allergies
  • medicines for high blood pressure
  • medicines for mental depression, anxiety, or other mood problems
  • nicotine
  • phenytoin
  • rifampin or rifabutin
  • some medicines used to treat irregular heartbeats

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

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